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261(19) 8977-8984).In contrast, when membrane bound prothrombin is activated by membrane bound prothrombinase, prothrombin activation continues by cleavage of Arg323 first, resulting in meizothrombin disulfide linked chains as an intermediate product, followed by the cleavage of meizotrombin in Arg274 to generate a thrombin-a and the activation of peptide fragment 1.2 (Krishnaswamy et al (1986) J Biol